Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene
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Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.
The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most colon cancers but also in some other cancers, such as those of the liver. The APC gene product is a 312 kDa protein that has multiple domains, through which it binds to various proteins, including beta-catenin, axin, CtBP, Asefs, IQGAP1, EB1 and microtubules. Studies ...
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Colorectal cancer (CRC) is mostly due to a series of genetic alterations that are being greatly under the influence of the environmental factors. These changes, mutational or epigenetic modifications at transcriptional forefront and/or post-transcriptional effects via miRNAs, include inactivation and the conversion of proto-oncogene to oncogenes, and/or inactivation of tumor suppressor genes (T...
متن کاملAlternatively spliced adenomatous polyposis coli (APC) gene transcripts that delete exons mutated in attenuated APC.
Reverse transcription-PCR combined with either (a) restriction enzyme digestion and repeat PCR or (b) ligase chain reaction has identified two new alternatively spliced transcripts of the adenomatous polyposis coli (APC) gene. In one of these transcripts exons 1-4 and the first 16 bases of exon 5 are deleted; in the other exons 2-4 and the first 16 bases of 5 are deleted. Both transcripts use a...
متن کاملThe Adenomatous Polyposis Coli (APC) tumor suppressor was identified as the gene mutated in specific families with a hereditary predisposition towards developing colorectal adenomatous polyps and carcinomas (Joslyn
The Adenomatous Polyposis Coli (APC) tumor suppressor was identified as the gene mutated in specific families with a hereditary predisposition towards developing colorectal adenomatous polyps and carcinomas (Joslyn et al., 1991; Kinzler et al., 1991). Truncation mutations in APC were subsequently also found in greater than 80% of sporadic colonic adenomatous polyps and carcinomas (Miyoshi et al...
متن کاملTumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2
Microtubules and their associated proteins (MAPs) underpin the polarity of specialised cells. Adenomatous polyposis coli (APC) is one such MAP with a multifunctional agenda that requires precise intracellular localisations. Although APC has been found to associate with kinesin-2 subfamily members, the exact mechanism for the peripheral localization of APC remains unclear. Here we show that the ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2007
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.03485